Letrozole (Femara)
An aromatase inhibitor increasingly used as first-line ovulation induction, particularly effective for women with PCOS.
Overview
Letrozole, originally developed as a breast cancer medication, has become a preferred first-line treatment for ovulation induction, especially in women with PCOS. By temporarily lowering estrogen production, it stimulates the pituitary to increase FSH, promoting follicle development with a lower risk of multiple pregnancies compared to clomiphene.
How It Works
Letrozole inhibits the aromatase enzyme, temporarily reducing estrogen production. The hypothalamus detects low estrogen and increases GnRH release, which stimulates FSH secretion from the pituitary. The resulting FSH surge promotes ovarian follicle development and ovulation.
Benefits
Potential Side Effects
Dosage Information
2.5-7.5mg daily for 5 days, starting on cycle day 3-5. The starting dose is typically 2.5mg, increasing if needed. Treatment is usually combined with cycle monitoring.
Administration
Oral tablet (5 days per cycle)
Rating
4.6 / 5.0
Category
Fertility Hormones
Common Symptoms
Allara Health
Insurance-covered care
Common Questions
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