Liothyronine (T3)
Synthetic T3 thyroid hormone used alone or in combination with T4 for patients who do not fully convert T4 to T3.
Overview
Liothyronine is synthetic triiodothyronine (T3), the most active thyroid hormone. Some patients with hypothyroidism do not adequately convert T4 to T3 and may benefit from combination therapy or T3 supplementation. It has a faster onset and shorter duration of action compared to T4.
How It Works
Liothyronine provides T3 directly to the body, bypassing the need for T4-to-T3 conversion. T3 enters cells and binds to thyroid hormone receptors in the nucleus, directly activating gene transcription that controls metabolic rate, energy production, and cellular function.
Benefits
Potential Side Effects
Dosage Information
Typical dose is 5-25mcg daily, often split into 2-3 doses due to its short half-life of about 24 hours. When used in combination with T4, the T4 dose is usually reduced.
Administration
Oral tablet (1-3 times daily)
Rating
4.3 / 5.0
Category
Thyroid Support
Common Symptoms
Common Questions
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